Cisplatin p53
WebFeb 28, 2024 · The p53 signaling pathway is involved in cisplatin-induced acute kidney injury (AKI). Western blot analysis showed that p53 was activated in the kidney ( Figures … WebThe group that received a combination of magnolol and cisplatin had the maximum expression of p53. ( b ) All treated groups showed significantly elevated levels of p21 …
Cisplatin p53
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WebFeb 28, 2024 · Our data revealed that p53 inhibition could attenuate cisplatin-induced acute kidney injury by up-regulating miR-142-5p to repress SIRT7/NF-κB. These findings may provide a novel therapeutic target of cisplatin-induced acute kidney injury. Keywords: Acute kidney injury, cisplatin, miR-142-5p, p53 Introduction WebHistopathological examination of cardiac muscles of all studied groups and immunoassay of P53 and caspase 3 in cardiac tissue were examined to assess apoptosis. Cisplatin has disturbed mitochondrial function and dynamics, dysregulate redox status and induced mitophagy and apoptosis, in the other hand semaglutide treatment has normalized ...
WebMay 26, 1998 · Cisplatin treatment of teratocarcinoma cells with a wild-type p53 gene resulted in accumulation of the p53 protein through posttranscriptional mechanisms; induction of p53-target genes was also observed. Drug treatment resulted in rapid apoptosis in p53-wild-type cells but not in p53 −/− teratocarcinoma cells. WebDuring cisplatin treatment, p53 was activated. The inhibition of p53 by pifithrin-α attenuated the cisplatin-induced kidney injury and up-regulated miR-142-5p expression. We also identified the Sirtuin7 (SIRT7) as a target of miR-142-5p.
WebIn human cells, the nucleotide excision repair (NER) process removes the intrastrand cross links from the genome, the efficiency of which is likely to be an important determinant of … WebOct 28, 2024 · The mutational status of p53 seems to be related to the preferential response of tumor cells to Wee1 inhibitors 21 – 23. Studies have shown that AZD1775 radiosensitized p53-defective human cells derived from lung, breast, and prostate cancers by abrogating the radiation-induced G2 block, while this was not observed in p53 wild-type cells 24 ...
WebCisplatin inhibited glycolysis via p53 activation. (A) Western blot analysis indicated increased levels of p53 and phospho-p53 after 6 and 24 h of cisplatin treatment. The …
WebWhen p53 was inhibited by 20 μM pifithrin-α (PFT-α) (Sigma-Aldrich) in cisplatin-treated cells and the expression levels of glycolysis-related genes were determined by qRT-PCR ( Fig 5 B), it... flower bunches imagesWebApr 11, 2024 · 2024年查处的不端行为案件处理结果通报（第一批次）. 近期，经国家自然科学基金委员会监督委员会调查审议、国家自然科学基金委员会委务会议审定，国家自然科学基金委员会对相关科研不端案件涉事主体进行了处理。. 现将给予通报批评的有关案情及处理 ... flower bunching machine for saleWebJan 30, 2024 · (D) Mechanism that CKI sensitizes p53-mutant CRC cells to cisplatin. The R273H/P309S mutation of p53 rendered CRC cells insensitive to Cis and 5FU treatments. The in vitro anti-CRC profiles of CKI + Cis combination were distinct from that of CKI+5FU. CKI decreased drug sensitivity to 5FU in both p53 wild and R273H/P309S mutation CRC … greek native americanWebp53 mediates cisplatin-induced apoptosis in renal proximal tubular cells, and p53 can activate caspase-3 . Related to this, Li et al. described that HRPTEp cells treated with … flower bunching machineWebJan 1, 2024 · The p53 and p21 proteins, which are senescence modulators, were upregulated at 48 h after cisplatin treatment ( Fig. 1 E and F). The mRNA levels of senescence-associated secretory phenotype (SASP) factors including interleukin (IL)-6, IL-1β, and tumor necrosis factor (TNF)-α were increased in NRK cells at 48 h after … greek natural cosmeticsWebThe average ID (50) (drug dose required to inhibit 50% of cell growth) for cell lines with mutant p53 was 6.8 microM, whereas the average ID (50) for cell lines with wild-type p53 … flower bunch for brideWebp53 mediates cisplatin-induced apoptosis in renal proximal tubular cells, and p53 can activate caspase-3 . Related to this, Li et al. described that HRPTEp cells treated with DDP for 48 h showed that DDP led to significantly upregulated miR-449a. In the same way, the overexpression of miR-449a led to an increased apoptotic rate of HRPTEpCs ... greek navy battleships