Citrinin pathway

Author: rkuf

August undefined, 2024

WebJul 6, 2024 · Detox Pathway: Dietary Supplement: Food: Ochratoxin Sterigmatocystin T-2 toxin (trichothecene) Zearalenone Alternaniol DON (deoxynivalenol) Glucoronidation: … WebTo learn more about the citrinin biosynthetic pathway, a ctnG-replacement vector was constructed to disrupt ctnG with the hygromycin resistance gene as the selection marker, then transformed into M. aurantiacus Li AS3.4384 by a protoplast-PEG method. The citrinin content of three disruptants was reduced to about 50%, meanwhile pigment ...

Citrinin C13H14O5 - PubChem

WebThe citrinin was completely detoxified by prior incubation with 0.05% hydrogen peroxide for 30 min at room temperature, and the toxic compound (s) that resulted from heating citrinin at 100 degrees C were also detoxified upon reheating it with hydrogen peroxide. WebNational Center for Biotechnology Information solo da no fear the rasmus

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WebJan 1, 2016 · Citrinin is a toxic secondary metabolite of Penicillium citrinum and its contamination in many food items has been widely reported. However, research on the citrinin biosynthesis pathway and its ... WebAug 31, 1987 · Despite the similarity in structures between citrinin and ochratoxin, the PKS (CitS) catalyzing of the first enzyme-free intermediate (redoxcitrinin) in the citrinin … WebCitrinin appears to be toxic by multiple pathways including inhibition of nucleic acid synthesis, inhibition of microtubule assembly and tubulin polymerization, alteration of … solo darling wrestler

The ctnF gene is involved in citrinin and pigment synthesis in …

The role of ER stress and ATP/AMPK in oxidative stress meditated ...

WebMay 27, 2024 · In our bodies, toxins are detoxed and excreted through a few pathways. Routes of elimination include urine, stool, bile and through our skin. Other routes include tears and saliva but are negligible in the realm of detoxification. ... This prebiotic has been shown to bind to citrinin, which a wide variety of molds produce. Using a variety of ... WebDec 17, 2015 · The pathway involves the synthesis of an unreduced trimethylated pentaketide 10 by a non-reducing polyketide synthase (nrPKS) known as CitS. Reductive … solodallas/the schaffer replicaWebApr 7, 2024 · Citrinin and additional polyketide biosynthesis genes (pksCT, ctnA, and Mga1, for example) have also been found . Citrinin production can be reduced or eliminated by manipulating culturing conditions [ 228 ], developing strains incapable of synthesizing citrinin by metabolic and genetic engineering [ 229 ], and simply screening for genera … solo dinghy association uk

"WebThe application of Monascus is restricted by citrinin. So, it is important to explore the synthetic pathway of citrinin to completely inhibit the production of citrinin. In our previous study, we found that the protein encoded by the ctnF gene has a significant similarity to fructose-2,6-bisphosphatase (F26BPase). " - Citrinin pathway

Citrinin pathway

The ctnG gene encodes carbonic anhydrase involved in mycotoxin citrinin …

WebFurthermore, citrinin activates some important factors involved in apoptosis, including p21-activated protein kinase 2 (PAK2) dependent pathways, caspase-3 and -9, c-Jun N-terminal kinase (JNK) and it raises reactive oxygen species (ROS) . Caspase-3 is famous as an executioner caspase in apoptosis. WebJun 1, 2007 · Abstract. The mycotoxin CTN (citrinin), a natural contaminant in foodstuffs and animal feeds, has cytotoxic and genotoxic effects on various mammalian cells. CTN …

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WebDec 6, 2014 · To learn more about the citrinin biosynthetic pathway, a ctnG-replacement vector was constructed to disrupt ctnG with the hygromycin resistance gene as the selection marker, then transformed into ... WebJun 28, 2024 · Citrinin targets the kidney, resulting in teratogenicity, carcinogenicity, and mutagenicity. Therefore, decreasing the content of citrinin is becoming a necessity that should be addressed as soon as possible. This study included a comprehensive transcriptomic analysis to elucidate the citrinin synthesis pathway in M. purpureus.

WebFeb 26, 2024 · When data mining was performed on citrinin targets, the top five functional descriptions were a cell’s response to an organic cyclic compound, the netrin–UNC5B … WebDec 16, 2024 · He, Y. Construction of a High-Efficiency Gene Knockout System of Monascus ruber M7 and Analysis of the Biosynthetic Pathway of Citrinin. Ph.D. Thesis, Huazhong Agricultural University, Wuhan, China, 2015; pp. 113–118. [Google Scholar] He, Y.; Cox, R.J. The molecular steps of citrinin biosynthesis in fungi.

WebMonascus aurantiacus produces high amounts of citrinin which is a mycotoxin with nephrotoxic activity. Six putative citrinin biosynthesis genes have been discovered in M. purpureus and at least 10 genes are responsible for its biosynthesis. However, the sequence of citrinin pathway gene cluster in M. aurantiacus has not been reported. WebFeb 21, 2024 · Citrinin is a toxic secondary metabolite of Penicillium citrinum and its contamination in many food items has been widely reported. However, research on the citrinin biosynthesis pathway and its regulation mechanism in P. citrinum is rarely reported. In this study, we investigated the effect of different carbon sources on citrinin production …

WebJun 28, 2024 · In addition, changes in transcription factor expression may also influence the network regulating the citrinin synthesis pathway in M. purpureus. Moreover, the yields of pigments produced by the ...

WebHence, many studies have focused on improving the ratio of monacolin K to citrinin through optimal cultivation or fermentation. Given that citrinin and monacolin K biosynthetic gene clusters are ... solo darth maulWebJan 1, 1999 · Biosynthesis of citrinin and synthesis of its biogenetic precursors L. Colombo, C. Gennari, D. Potenza, C. Scolastico, F. Aragozzini, C. Merendi Chemistry 1980 … small battery tester walmartWebSep 29, 2011 · CIT is synthesized via the polyketide pathway [20]. It is generally known that three secondary metabolites, pigments, monacolin K, and citrinin, share a biochemical … sol odeint dy 0 x solo dinghy inhaulWebSep 29, 2011 · In the citrinin biosynthesis pathway, the transcriptional activator (ctnA) is one of the important components in the citrinin cluster [53]. According to our qRT-PCR analysis (Figure 3B), the ... solo de bohemian rhapsodyWebJun 1, 2024 · Citrinin, a secondary metabolite, can pose serious risks to the environment and organisms, but its hepatotoxic mechanisms are still unclear. ... (ATP), activating AMPK pathway in L02 cells. Eventually, pretreatment with NAC, an ROS inhibitor, alleviates citrinin-induced cell cycle G2/M arrest and apoptosis by inhibiting ROS-mediated ER … small battery travel clockWebYes. Some red yeast rice products contain a contaminant called citrinin, which is toxic and can damage the kidneys. In a 2024 analysis of 37 red yeast rice products, only one had citrinin levels below the maximum … small battery tree limb cutter